People typically die from progressive supranuclear palsy within 7 to 10 years. There is currently no specialized treatment or effective screening for this neurodegenerative disease.
Articles on Tau
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Scientists discover that ‘toxic’ Alzheimer’s protein is essential for baby brain development.
Helicobacter pylori, best known for causing stomach ulcers, was shown to block the build-up of both amyloid-beta and tau in our study.
Tau behaves abnormally in the brain in people with Alzheimer’s disease. This latest study points to a reason why.
Tau neutrinos are notoriously difficult to spot in detectors like IceCube. But researchers have managed to isolate 7 candidates.
Physicists uncovered a new experiment hidden in old data from the Large Hadron Collider. Using this innovative approach, the team has unlocked an entirely new way to study quantum physics.
In clinical trials, lecanemab slowed disease progression by 27% and reduced the amount of plaque found in the brains of those with Alzheimer’s disease.
PET scans using a special tracer can pick up ‘tau tangles’ in the brain.
The new drug is based on the idea that a build-up of amyloid in the brain leads to the disease. But that hypothesis has been under scrutiny lately.
Knowing what cells are more vulnerable could some day help researchers know why these cells are more vulnerable than others.
We now have the technology to identify people who are on a fast track to developing dementia.
After the failure of multiple drug trials the outlook for an Alzheimer’s drug is bleak. This shouldn’t be a surprise. We don’t know the cause or even how to diagnose the disease.
Not all drug development needs to start from scratch. Sometimes researchers discover that a drug developed for one disease can be used for another. Here a cancer drug may show promise for dementia.
Many pieces leading to Alzheimer’s disease have been identified. To put the pieces together, one scholar argues that the government should launch a Manhattan Project-scale effort to find a cure.
Have you noticed your thinking ability drops during winter and spring? A new study of healthy adults and dementia patients found cognitive function declines in the colder months.
Alzheimer’s drug development tends to focus on protein aggregates in the brain. Perhaps that’s why they’ve all failed.
Top contributors
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PhD Candidate, Neuroscience, University of Sheffield
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Professor of Neurology and Neurotherapeutics, UT Southwestern Medical Center
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Research Fellow, Harvard Medical School, Research Fellow, Florey Institute of Neuroscience and Mental Health
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Professor of Physics and Professor of Astronomy and Astrophysics, Penn State
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Research Fellow in Neuroimmunology, UCL
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Étudiant au doctorat en psychologie, Université du Québec à Montréal (UQAM)
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Assistant Professor of Physics, New York University
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Professor of cognitive pharmacology, Université du Québec à Montréal (UQAM)
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Professor of Neurology, University of Miami
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Postdoctoral Researcher, Karolinska Institutet
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Professor of Medicine, Dartmouth College
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Associate Professor of Physics, University of Colorado Boulder
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Senior Clinical Researcher, Dementia, University of Oxford
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Professor of Neuroscience, University of California, Santa Barbara
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Associate professor, Karolinska Institutet