Articles on T cells

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Treg cells have been thrust into the limelight thanks to the Nobel Prize-winning work of a team of researchers from the U.S. and Japan. jarun011/iStock via Getty Images Plus

How pollution and the microbiome interact with Tregs, the immune system regulators whose discovery was honored with the Nobel Prize

Researchers are gaining insights into how external factors like air pollutants, diet and medications, and even microbes in the gut interact with regulatory T cells, for better or for worse.
Regulatory T cells (red) interact with other immune cells (blue) and modulate immune responses. National Institute of Allergy and Infectious Diseases/NIH via Flickr

How does your immune system stay balanced? A Nobel Prize‑winning answer

Regulatory T cells help your immune system distinguish between ‘self’ and ‘nonself’ – and can open doors to better treatments for cancer, autoimmune disease and transplant rejection.
Understanding the flexibility of T cell memory can lead to improved vaccines and immunotherapies. Juan Gaertner/Science Photo Library via Getty Images

Immune cells can adapt to invading pathogens, deciding whether to fight now or prepare for the next battle

When faced with a threat, T cells have the decision-making flexibility to both clear out the pathogen now and ready themselves for a future encounter.
When immune cells become overactive, your immune system itself can cause disease. NIAID/Flickr

Immune health is all about balance – an immunologist explains why both too strong and too weak an immune response can lead to illness

Dietary supplements claim to be able to ‘boost your immune system’ to combat disease. But attaining immune balance through a healthy lifestyle and vaccination is a safer bet to keep in good health.
This microscopy image shows a cytotoxic T cell (blue) attacking a cancer cell (green) by releasing toxic chemicals (red). Alex Ritter and Jennifer Lippincott Schwartz and Gillian Griffiths/National Institutes of Health via Flickr

Immune cells that fight cancer become exhausted within hours of first encountering tumors – new research

T cells recognize and kill cancer cells but quickly lose their effectiveness. This fast dysfunction may help explain why immunotherapy doesn’t lead to long-term remission for many patients.
Killer T cells (green and red), or cytotoxic T cells, surround a cancer cell (blue, center). NICHD/J. Lippincott-Schwartz

Anti‑cancer CAR‑T therapy reengineers T cells to kill tumors – and researchers are expanding the limited types of cancer it can target

Immunotherapy has the potential to eliminate tumors, but works best for select patients. Engineering T cells to bypass cancer’s defenses could help expand treatment eligibility to more patients.
Insect bites or stings, like the one on this person’s hand, are a manifestation of inflammation. Suthep Wongkhad/EyeEm via Getty Images

What is inflammation? Two immunologists explain how the body responds to everything from stings to vaccination and why it sometimes goes wrong

Inflammation is a complicated and important part of how the immune system responds to threats to the body. But when the inflammatory response goes awry, it can lead to serious problems.
Stem cell transplants involve completely eliminating and then replacing the immune system of a patient, often by transplanting the bone marrow. xia yuan/Moment via Getty Images

Gut bacteria nurture the immune system – for cancer patients, a diverse microbiome can protect against dangerous treatment complications

Patients with blood cancer undergoing stem cell transplantation have a high risk of complications. The bacteria in their gut, however, can help their immune system recover and fight infections.
Immunosenescence, or immune aging, can lead to less effective responses to vaccines and greater vulnerability to invading pathogens. Kudryavtsev Pavel/iStock via Getty Images Plus

Social stress can speed up immune system aging – new research

While the immune system naturally gets weaker with age, social stressors like trauma and discrimination can hasten immunosenescence.
Dendritic cells (green) produce cytokines like IL-12, which can train T cells (pink) to attack tumors. Victor Segura Ibarra and Rita Serda/National Cancer Institute via Flickr

‘Masked’ cancer drug stealthily trains immune system to kill tumors while sparing healthy tissues, reducing treatment side effects

One promising cancer treatment has been in the works for decades, but severe side effects have kept it out of the clinic. A reengineered version may offer a way to safely harness its potent effects.

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