Articles on Immunotherapy

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With a little help, your immune cells can be potent tumor killers. Steve Gschmeissner/Science Photo Library via Getty Images

COVID‑19 mRNA vaccines could unlock the next revolution in cancer treatment – new research

The researchers found that mRNA-based COVID-19 vaccines could potentially help patients whose tumors don’t respond well to traditional immunotherapy.
Regulatory T cells (red) interact with other immune cells (blue) and modulate immune responses. National Institute of Allergy and Infectious Diseases/NIH via Flickr

How does your immune system stay balanced? A Nobel Prize‑winning answer

Regulatory T cells help your immune system distinguish between ‘self’ and ‘nonself’ – and can open doors to better treatments for cancer, autoimmune disease and transplant rejection.
How cancer vaccines are delivered into the body influences their effectiveness. Liuhsihsiang/iStock via Getty Images Plus

Brain cancer in children is notoriously hard to treat – a new mRNA cancer vaccine triggers an attack from within

Cancer vaccines have gained much interest among scientists but face a number of hurdles. A new mRNA vaccine for glioma offers a step forward in training the immune system to fight cancer.
This microscopy image shows a cytotoxic T cell (blue) attacking a cancer cell (green) by releasing toxic chemicals (red). Alex Ritter and Jennifer Lippincott Schwartz and Gillian Griffiths/National Institutes of Health via Flickr

Immune cells that fight cancer become exhausted within hours of first encountering tumors – new research

T cells recognize and kill cancer cells but quickly lose their effectiveness. This fast dysfunction may help explain why immunotherapy doesn’t lead to long-term remission for many patients.
Gain-of-function experiments in the lab can help researchers get ahead of viruses naturally gaining the ability to infect people in the wild. KTSDesign/Science Photo Library via Getty Images

Gain‑of‑function research is more than just tweaking risky viruses – it’s a routine and essential tool in all biology research

From cancer immunotherapy and antibiotics to GMO crops and pandemic surveillance, gain of function is a cornerstone of basic research.
Most tumors are made up of many different kinds of cancer cells, as shown in this pancreatic cancer sample from a mouse. Ravikanth Maddipati/Abramson Cancer Center at the University of Pennsylvania via National Cancer Institute

Every cancer is unique – why different cancers require different treatments, and how evolution drives drug resistance

There is no one-size-fits-all approach to treating cancer. Understanding how cancer cells evolve could help researchers develop more effective drugs.

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