Articles on Cancer immunotherapy

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This microscopy image shows a cytotoxic T cell (blue) attacking a cancer cell (green) by releasing toxic chemicals (red). Alex Ritter and Jennifer Lippincott Schwartz and Gillian Griffiths/National Institutes of Health via Flickr

Immune cells that fight cancer become exhausted within hours of first encountering tumors – new research

T cells recognize and kill cancer cells but quickly lose their effectiveness. This fast dysfunction may help explain why immunotherapy doesn’t lead to long-term remission for many patients.
Gain-of-function experiments in the lab can help researchers get ahead of viruses naturally gaining the ability to infect people in the wild. KTSDesign/Science Photo Library via Getty Images

Gain‑of‑function research is more than just tweaking risky viruses – it’s a routine and essential tool in all biology research

From cancer immunotherapy and antibiotics to GMO crops and pandemic surveillance, gain of function is a cornerstone of basic research.
Most tumors are made up of many different kinds of cancer cells, as shown in this pancreatic cancer sample from a mouse. Ravikanth Maddipati/Abramson Cancer Center at the University of Pennsylvania via National Cancer Institute

Every cancer is unique – why different cancers require different treatments, and how evolution drives drug resistance

There is no one-size-fits-all approach to treating cancer. Understanding how cancer cells evolve could help researchers develop more effective drugs.
Killer T cells (green and red), or cytotoxic T cells, surround a cancer cell (blue, center). NICHD/J. Lippincott-Schwartz

Anti‑cancer CAR‑T therapy reengineers T cells to kill tumors – and researchers are expanding the limited types of cancer it can target

Immunotherapy has the potential to eliminate tumors, but works best for select patients. Engineering T cells to bypass cancer’s defenses could help expand treatment eligibility to more patients.
Dendritic cells (green) produce cytokines like IL-12, which can train T cells (pink) to attack tumors. Victor Segura Ibarra and Rita Serda/National Cancer Institute via Flickr

‘Masked’ cancer drug stealthily trains immune system to kill tumors while sparing healthy tissues, reducing treatment side effects

One promising cancer treatment has been in the works for decades, but severe side effects have kept it out of the clinic. A reengineered version may offer a way to safely harness its potent effects.
Former President Jimmy Carter pictured at an Atlanta Braves-Toronto Blue Jays game in Atlanta on Sept. 17, 2015, shortly after being treated for melanoma. AP Photo/John Bazemore

Cancer deaths decline in US, with advances in prevention, detection and treatment

Cancer mortality has dropped in the US, due largely to lower smoking rates, as well as early detection and better treatments. These advances often do not extend to people in developing nations.
A woman holds her stomach in agony from ulcerative colitis. Emily Frost / Shutterstock.com

Stool transplantation shows promise treating cancer therapy side effect

Cancer immunotherapy is a revolutionary treatment for many but it can cause nasty side effects like inflammation of the colon that can derail treatment. Could the solution be a fecal transplant?

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