The results of Novo Nordisk’s phase 1 trials shows the oral weight loss pill could be more effective than semaglutide.
Articles on Wegovy
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We need to take stock of the promises and limitations of new “miracle” weight loss drugs such as Ozempic, Mounjaro and Wegovy.
The weight-loss drug Wegovy is now in Australia. Here’s what the science says about the potential benefits and risks of taking it.
As far back as the 19th century, teenage girls have been warned about the dangers of weight loss “quack medicines”.
Diabetes drugs similar to Ozempic are associated with a reduction in risk of ten types of cancer compared with treatment with insulin.
The future of the blockbuster drugs could hinge on a trial in Pennsylvania.
The animal studies are promising but early research in humans show mixed results. Here’s what we know so far.
Some women who use drugs like Ozempic have reported unexpected pregnancies. What’s going on?
Does weight come back when you stop taking drugs like Ozempic? Are these medications simply another (expensive) form of yo-yo dieting? Here’s what we know so far.
We don’t tell people taking statins to treat high cholesterol or drugs to manage high blood pressure they’re cheating or taking the easy way out. Nor should we when people take drugs like Ozempic.
In Australia, Ozempic is only approved to treat diabetes but doctors are prescribing it ‘off label’ for weight loss. Compounding pharmacies have also been making their own versions to meet demand.
Ozempic generated A$21 billion of sales in 2023 alone. So how was it developed? And how are its new competitors, Mounjaro and Zepbound, different?
Early on we heard a lot about the potential benefits of drugs like Ozempic. Now we’re hearing more about the risks. But what does the latest evidence say?
The demand for off-label weight loss drugs like Ozempic is concerning, because of the impact on weight stigma and the health risks of unsupervised weight loss, including developing eating disorders.
Weight loss and diabetes drugs target regulatory pathways involved in metabolism that the microbes in your gut and certain molecules from food already play a key role in regulating.
Medications can play an important role in weight management, but not at the expense of overall nutrition. And healthy lifestyle habits are also key.
When people stopped taking one of the new weight-loss jabs they regained around 60% of their lost weight.
People who are obese, as well as those who are overweight and have weight-related issues, may soon be able to ask their doctor for a prescription.
In trials, Mounjaro was shown to be more effective than Ozempic in managing type 2 diabetes.
The Conversation has been following the trials and tribulations of semaglutide (Wegovy) as it made its way from lizard venom to blockbuster drug.
Top contributors
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Associate Professor of Metabolic Medicine, University of Surrey
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Associate Professor of Physiology and Medical Education, Anglia Ruskin University
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Professor of Health Service Operations, School of Pharmacy & Medical Sciences, University of Bradford
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General Practitioner, PhD Candidate, Bond University
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Research Lead/Advanced Clinical Practitioner/Senior Research Fellow, University of Bradford
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Professor of Community Health and Wellbeing, The University of Queensland
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Associate Professor in Pharmacy Practice, University of Bradford
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Clinical Epidemiologist, Washington University in St. Louis
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Accredited Practising Dietitian and Lecturer, Southern Cross University
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Senior Lecturer, Pharmacy, Aston University
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ARC Future Fellow, School of Biomedical Sciences, The University of Queensland
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Associate Professor of Nutrition, University of Surrey
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Professor of Pharmaceutical Chemistry, Macquarie University
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Associate Professor of Gastroenterology, School of Medicine, University of Washington
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Honorary Associate Professor, University of Leicester