Articles on Opioid overdose

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In March 2023, the U.S. Food and Drug Administration approved naloxone as a nonprescription nasal spray to reverse the effects of an opioid overdose. Michael Siluk/UCG/Universal Images Group via Getty Images

Animal tranquilizers found in illegal opioids may suppress the lifesaving medication naloxone − and cause more overdose deaths

Increasingly, these types of tranquilizers are turning up in fentanyl, oxycodone and other illegal opioids.
A registered nurse treats Dominic Rodriguez for a skin injury related to xylazine use in Philadelphia in May 2023. Treatment vans are allowed in the city, but not supervised injection sites. Matt Rourke/AP Photo

Philadelphia bans supervised injection sites – evidence suggests keeping drug users on the street could do more harm than good

A group of academics look at the global evidence to examine the potential impact of supervised injection sites in Philadelphia and the US.
Opioid neurotransmitters are located in many areas of the body, including the brain, spine and gut. ALIOUI Mohammed Elamine/iStock via Getty Images Plus

Your body naturally produces opioids without causing addiction or overdose – studying how this process works could help reduce the side effects of opioid drugs

Unlike opioid drugs like morphine and fentanyl that travel throughout the body, the opioids your body produces are released in small quantities to specific locations.
The use of naloxone administered by nasal spray can be a lifesaving drug with minimal side effects. TG23/iStock via Getty Images Plus

FDA approval of over‑the‑counter Narcan is an important step in the effort to combat the US opioid crisis

The Food and Drug Administration’s approval of Narcan will make the lifesaving drug more widely available, especially to those who might be likely to witness or respond to opioid overdoses.
Although xylazine is not an opioid, naloxone can reverse the effects of the fentanyl and heroin it is often mixed with. AP Photo/Jae C. Hong

What is xylazine? A medical toxicologist explains how it increases overdose risk, and why Narcan can still save a life

Xylazine, or tranq, is increasingly being mixed with drugs like fentanyl or heroin and can be difficult to detect. Most people who use drugs are unable to tell if they have been exposed to it.
The cannabis plant produces both THC – the psychoactive component in marijuana – and the compound commonly known as CBD, which does not lead to a ‘high.’ Jena Ardell/Moment via Getty Images

Cannabis holds promise for pain management, reducing the need for opioid painkillers – a neuropharmacology expert explains how

Studies suggest that marijuana and CBD use might help relieve chronic pain while also reducing a patient’s need for opioids.
A part of the brain called the lateral parabrachial nucleus regulates pain, anxiety and breathing. Aleksei Morozov/iStock via Getty Images Plus

Pain and anxiety are linked to breathing in mouse brains – suggesting a potential target to prevent opioid overdose deaths

Opioids can cause death by slowing breathing to dangerously low levels, or stopping it altogether. Examining one area of the brain may eventually lead to safer painkillers.

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