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A mural in Rome depicts a white dove parachuting vials of COVID-19 vaccine. Several COVID-19 vaccines are based on a viral vector developed by Canadian Frank Graham decades ago. (AP Photo/Gregorio Borgia)

How the puzzle of viral vector vaccines was solved, leading to today’s COVID‑19 shots

Viral vectors are modified viruses that trigger an immune response without causing infection. The vector that’s used in several COVID-19 vaccines was created decades ago by Canadian Frank Graham.
There are many ways to make a vaccine. In a time of crisis, the more paths towards success the better. Adriana Duduleanu / EyeEm via Getty Images

Labs are experimenting with new – but unproven – methods to create a coronavirus vaccine fast

Under pressure to develop a coronavirus vaccine, researchers have turned to protein synthesis, genetics and hybrid viruses. It is likely a mix of these approaches will be used to fight the coronavirus.

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