Ayahuasca has been used for spiritual and therapeutic purposes by indigenous healers in Brazil’s northwestern Acre state for centuries. Luna Parracho/Reuters November 11, 2016 Can Ayahuasca, the ‘sacred plant’ of the Amazon, help addiction and depression? Rafael Guimarães dos Santos, Universidade de São Paulo (USP) Western science is “discovering” the medical potential of ayahuasca, which Amazonian indigenous groups have used ritualistically for centuries.