Kory London – The Conversation

Medetomidine is now a key ingredient in street fentanyl sold in Philly. AP Photo/Matt Rourke

March 26, 2025

Medetomidine is replacing xylazine in Philly street fentanyl − creating new hurdles for health care providers and drug users

Kory London, Thomas Jefferson University and Karen Alexander, Thomas Jefferson University

An emergency physician and nurse scientist explain what medetomidine is and how to respond if someone is overdosing on it.

Opioid overdose deaths in Philly dropped in 2023. Data for 2024 has not yet been released. Jeff Fusco/The Conversation U.S.

March 17, 2025

Fewer deaths, new substances and evolving treatments in Philly’s opioid epidemic − 4 essential reads

Kate Kilpatrick, The Conversation

Philly’s opioid addiction crisis is constantly evolving. Local health care workers and researchers explain some of the latest substances, side effects and treatments.

Patients suffering withdrawal from fentanyl and xylazine can require intensive care. SDI Productions/E+ Collection via Getty Images

October 16, 2024

Philly hospitals test new strategy for ‘tranq dope’ withdrawal – and it keeps patients from walking out before their treatment is done

Kory London, Thomas Jefferson University

The combination of fentanyl and xylazine that dominates Philadelphia’s illegal dope supply creates agonizing withdrawal symptoms. This presents new challenges for doctors and nurses.

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