Jonathan Simone

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I hold a PhD in Neurobiology and I am currently an Adjunct Professor of Biological Sciences at Brock University where I specialize in the neurodevelopmental effects and behavioural pharmacology of cannabis, cannabinoids, and the endocannabinoid system. I have published 17 peer-reviewed papers in leading scientific journals, with several more currently under review, and have received numerous research awards for my work.

Beyond academia, I have contributed an invited book chapter on the state of medical cannabis in Canada, exploring how international markets can leverage Canada’s regulatory framework to expand their programs. I have also served as Co-Chair of the Medical and Scientific Advisory Committee for Medical Cannabis Canada and as Director of Research and Clinical Studies for Aphria Inc., one of the largest producers of cannabis worldwide. Additionally, I have developed several novel drug formulation and delivery patents for psychedelic compounds, which are currently filed with the USPTO.

Experience

  • 2019–present
    Adjunct assistant professor, Brock University

Education

  • 2018 
    Brock University, PhD in Neurobiology and Physiology

Publications

  • 2025
    Down the Rabbit Hole: A Large-Scale Survey of Psychedelic Users' Patterns of Use and Perceived Effects, Journal of Psychoactive Drugs
  • 2023
    Insights into the endocannabinoid system from investigations of the development of social behavior in rodents of both sexes, Neurobiology and Physiology of the Endocannabinoid System
  • 2022
    Endocannabinoid system contributions to sex-specific adolescent neurodevelopment, Progress in Neuro-Psychopharmacology and Biological Psychiatry
  • 2022
    Dissociable changes in spike and wave discharges following exposure to injected cannabinoids and smoked cannabis in Genetic Absence Epilepsy Rats from Strasbourg, European Journal of Neuroscience
  • 2021
    The endocannabinoid system and invertebrate neurodevelopment and regeneration, International Journal of Molecular Sciences
  • 2020
    Adolescent CB1 receptor antagonism influences subsequent social interactions and neural activity in female rats, International Journal of Developmental Neuroscience
  • 2020
    Cannabinoids in chronic non-cancer pain: a systematic review and meta-analysis, Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders
  • 2018
    Sex-specific effects of CB1 receptor antagonism and stress in adolescence on anxiety, corticosterone concentrations, and contextual fear in adulthood in rats, International Journal of Developmental Neuroscience
  • 2018
    Effects of CB1 receptor antagonism and stress exposures in adolescence on socioemotional behaviours, neuroendocrine stress responses, and expression of relevant proteins in the hippocampus and prefrontal cortex in rats, Neuropharmacology
  • 2018
    ENDOCANNABINOID REGULATION OF ADOLESCENT DEVELOPMENT IN MALE AND FEMALE RATS, Brock University Press
  • 2018
    Effects of long-term dietary administration of estrogen receptor-beta agonist diarylpropionitrile on ovariectomized female ICR (CD-1) mice, Geoscience
  • 2017
    Intracellular signalling and plasma hormone profiles associated with the expression of unconditioned and conditioned fear and anxiety in female rats, Physiology and Behaviour
  • 2017
    Translational relevance of rodent models of hypothalamic-pituitary-adrenal function and stressors in adolescence, Neurobiology of Stress
  • 2016
    Glucocorticoid receptor translocation and expression of relevant genes in the hippocampus of adolescent and adult male rats, Psychoneuroendocrinology
  • 2015
    Differential effects of CB1 receptor agonism in behavioural tests of unconditioned and conditioned fear in adult male rats, Behavioural Brain Research
  • 2015
    Effects of CB1 receptor agonism and antagonism on behavioral fear and physiological stress responses in adult intact, ovariectomized, and estradiol-replaced female rats, Neuroscience
  • 2015
    Peer pressures: Social instability stress in adolescence and social deficits in adulthood in a rodent model, Developmental Cognitive Neuroscience
  • 2014
    Effects of social context on endocrine function and Zif268 expression in response to an acute stressor in adolescent and adult rats, International Journal of Developmental Neuroscience
  • 2013
    Age and adolescent social stress effects on fear extinction in female rats, Stress

Contact Jonathan for

  • General
  • Media request
  • Speaking request
  • Consulting / Advising
  • Research collaboration