Jean-Michel Fustin

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Jean-Michel Fustin is a UKRI Future Leaders Fellow and Senior Research Fellow in Integrative Physiology at the University of Manchester. His research explores how metabolism, nutrition and gene regulation interact with the biological clock, with work published in journals including Cell, Nature Communications and Science Advances.
Originally from Belgium, he trained across Europe and Japan before settling in the UK, bringing an international perspective to questions of science, education and academic culture. Alongside his research, he teaches endocrinology and physiology, including sexual development and the biological basis of behaviour. His students' strong interest in these topics has motivated a wider interest in public engagement and science communication.
Through his writing, he aims to make complex biological questions accessible to general audiences, particularly where science intersects with public debate. His work has been featured in national media including The Guardian.

Experience

  • 2026–present
    Senior Research Fellow, University of Manchester
  • 2020–2026
    Research fellow, University of Manchester
  • 2018–2020
    Associate Professor, Kyoto University
  • 2014–2018
    Adjunct Lecturer, Kyoto University
  • 2013–2014
    Post-Doctoral Researcher, Kyoto University
  • 2011–2013
    Post-doctoral Fellow, The Association for Preventive Medicine of Japan (Kyoto University)
  • 2009–2011
    Post-doctoral Fellow, Japan Society for the Promotion of Science (Kyoto University)
  • 2008–2009
    Post-doctoral Fellow, Japan Society for the Promotion of Science (Kyoto University)
  • 2009–2009
    Post-doctoral Fellow, Takeda Science Foundation (Kyoto University)
  • 2001–2004
    Research assistant, University of Aberdeen/Rowett Research Institute

Education

  • 2008 
    University of Aberdeen, PhD/Biological Sciences
  • 1999 
    University of Namur, Bsc. in Biology
  • 1999 
    University of Namur, PGCE

Publications

  • 2026
    Nutrigenomic regulation of one-carbon metabolism and the circadian clock in health and disease, Journal of Biochemistry
  • 2026
    A high-resolution, sex-stratified atlas of transcriptional and alternative splicing dynamics in the fasting mouse liver, bioRxiv
  • 2025
    Somatostatin regulates the clock sensitivity to evening light, Scientific Report
  • 2025
    Guanine is an inhibitor of c-Jun terminal kinases, Scientific Report
  • 2024
    Improved CaP Nanoparticles for Nucleic Acid and Protein Delivery to Neural Primary Cultures and Stem Cells, ACSnano
  • 2023
    Timed exercise stabilizes behavioral rhythms but not molecular programs in the brain's suprachiasmatic clock., iScience
  • 2022
    Excess S-adenosylmethionine inhibits methylation via catabolism to adenine., Communications Biology
  • 2022
    Methyl Metabolism and the Clock: An Ancient Story With New Perspectives. J Biol Rhythms., Journal of Biological Rhythms
  • 2021
    Hyperpolyploidization of hepatocyte initiates preneoplastic lesion formation in the liver., Nature Communications
  • 2020
    S-adenosyl-l-homocysteine hydrolase links methionine metabolism to the circadian clock and chromatin remodeling., Science Advances
  • 2020
    Methylation deficiency disrupts biological rhythms from bacteria to humans., Communications Biology

Grants and Contracts

  • 2020
    Methylation of mRNA as a coupling mechanism between diet, metabolism and the circadian clock.
    Role:
    PI
    Funding Source:
    Medical Research Council

Contact Jean-Michel for

  • General
  • Media request
  • Speaking request
  • Consulting / Advising
  • Research collaboration
  • Research supervision