Isabelle Broutin

Isabelle Broutin is currently the team leader of the group “Membrane transport and signaling” at the university Paris Cite ́. She is a member of different commissions of trust, such as the direction comity of the doctoral schools MTCI (University Paris Cite ́), the scientific peer review comity for SOLEIL synchrotron (France), and the local scientific council (CSL) of the faculty of pharmacy.
She followed a formation of physicists at Orsay University, France, before becoming interested in structural biology. After obtaining a Ph.D. in 1993 on the resolution of the 3D structure of a serine collagenase from a cattle parasite, she performed a post-doctoral study in Uppsala, Sweden, on the 3D structure of CRBP. She was recruited in 1997 to the National Center of Scientific Research (CNRS), France, and was involved in studying cellular signal transduction proteins (Grb2, Grb14, VEGFR, PRLR). She took the direction of the group “signaling and membrane transport” in 2008. Since 2016, she has been Deputy Director of the CiTCoM laboratory, grouping structural biologists with chemists with the common goal of developing therapeutic drugs targeting diseases that are considered major public health problems. Her team works at the comprehension at the molecular level of the functional mechanism of the different protein actors involved in antibiotic resistance, with recognized expertise in the structural biology of membrane proteins. She has published over 80 manuscripts, book chapters, and reviews, and her recent work has provided important information for the comprehension of the assembly and opening mechanism of RND tripartite efflux pumps, as illustrated by the structure of the MexAB-OprM efflux pump from P. aeruginosa (Glavier, Nat Com 2020).