Havovi Chichger

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Havi is a cell and molecular biologist. Her research focuses on the molecular mechanisms which underlie endothelial and epithelial physiology. Alongside her role as Professor in Biomedical Science, Havi is Deputy Head of School (Research, Innovation & Income Generation).

In 2011, Havovi earned her doctorate in physiology from University College London, which focused on studying the role of renal and small intestinal glucose transport across the epithelium in metabolic syndrome and diabetes.

As a Postdoctoral Fellow at Brown University, Havovi's research developed into vascular dysfunction in settings of disease including respiratory disease. During her Post-Doctorate, she was awarded significant funding from the American Heart Association, published several peer-reviewed articles and participated in numerous clinical and basic research conference presentations (including invited and peer-reviewed oral presentations) on renal glucose transport, endocytosis, vascular function and respiratory disease.

Currently, Havovi is continuing her research on mechanisms which regulate endothelial and epithelial barrier function, with an emphasis on novel regulators of both barriers, such as the taste receptor. She leads the Biomedical Research Group.

Research interests:

Physiological roles of bitter and sweet taste receptors
Renal and small intestinal glucose transport across the epithelium (diabetes, metabolic syndrome)
Mechanisms regulated by artificial sweeteners and sweet taste receptors (diabetes, pulmonary diseases)
Endosomal trafficking in the vasculature (pulmonary diseases)
Protein phosphatase (PTP and SHP2) signalling (pulmonary diseases)
Protein kinases (PKC and MAPK) signalling (diabetes, pulmonary diseases)
Novel mechanisms regulating microvascular complications (diabetes, pulmonary diseases)
Molecular mechanisms which link the gut microbiota and gastric permeability

Experience

  • –present
    Senior Lecturer, Anglia Ruskin University
  • 2011–2015
    Postdoctoral research fellow, Brown University

Education

  • 2011 
    University College London, PhD in Physiology
  • 2004 
    King's College London, BSc Biochemistry

Publications

  • 2017
    Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: A mechanism underlying RV fibrosis associated with cigarette smoke exposure. , American Journal of Physiology – Lung Cellular and Molecular Physiology.
  • 2016
    Select Rab GTPases regulate the pulmonary endothelium via endosomal trafficking of VE-cadherin. , American Journal of Respiratory Cell and Molecular Biology.
  • 2016
    Differential regulation of renal glucose transporters: Implications for diabetic nephropathy. , Experimental Physiology.
  • 2015
    p18, a novel adaptor protein, regulates pulmonary endothelial barrier function via enhanced endocytic recycling of VE-cadherin. , FASEB Journal
  • 2015
    SHP2 and FAK protein interactions regulate pulmonary endothelium barrier function. , American Journal of Respiratory Cell and Molecular Biology.
  • 2015
    PKC δ and βII Regulate Angiotensin II Mediated Fibrosis through p38: A Mechanism of RV Fibrosis in Pulmonary Hypertension. , American Journal of Physiology – Lung Cellular and Molecular Physiology.
  • 2015
    Vasculogenesis in the pulmonary endothelium is regulated by the endosome: Rab4-mediated trafficking and p18-dependent signaling. , American Journal of Physiology – Lung Cellular and Molecular Physiology.
  • 2013
    Luminal proteolytic activation of the collecting duct epithelial sodium channel (ENaC) and its possible role in renal sodium reabsorption in vivo. , Nephrology Dialysis Transplantation.
  • 2012
    Protection against LPS-induced pulmonary edema through the attenuation of PTP1B oxidation. , American Journal of Respiratory Cell and Molecular Biology.
  • 2012
    Genetic Disruption of PKCδ Reduces Endotoxin-Induced Lung Injury. , American Journal of Physiology-Lung Cellular and Molecular Physiology.
  • 2012
    Investigation of Protein kinase C Isoforms in the Formation of Focal Adhesion Complexes by ECIS. , Cancer, Metastasis, Biology and Treatment: Electric Cell-Substrate Impedance Sensing in Cancer and Cancer Metastasis Research
  • 2006
    On the mechanism of sequence-specific DNA-dependent acetylation of p53: The acetylation motif is exposed upon DNA binding., Journal of Molecular Biology.

Grants and Contracts

  • 2016
    Artificial Sweeteners reduce Diabetes-Induced Vascular Permeability through Sweet Taste Receptor Signalling Pathways
    Role:
    Principal investigator
    Funding Source:
    Diabetes UK
  • 2016
    Artificial Sweeteners reduce Diabetes-Induced Vascular Permeability through Sweet Taste Receptor Signalling Pathways
    Role:
    Principal investigator
    Funding Source:
    Wellcome Trust
  • 2013
    Mechanisms Regulating the Pulmonary Endothelium through VE-Cadherin Trafficking
    Role:
    Principal investigator
    Funding Source:
    American Heart Association

Contact Havovi for

  • Media request
  • Speaking request
  • Research collaboration
  • Research supervision