• Professor of Chemistry and Senior Scientist of the Krembil Research Institute, University Health Network, University of Toronto
In Alzheimer’s disease, a strong case exists for concurrently using multiple drugs hitting multiple targets. (Shutterstock)

Curing Alzheimer’s disease: Magic bullet or magic shotgun blast?

Rather than seeking a single cure — a magic bullet — for Alzheimer’s disease, a shotgun blast of different drugs with different targets may be a better approach to this very complex condition.
Una nueva teoría de la enfermedad de Alzheimer reevalúa el papel del beta-amiloide en el cerebro. (AP Photo/Evan Vucci)

Hay motivos para sospechar que el alzhéimer podría ser una enfermedad autoinmune

Los científicos llevan años concentrados en resolver el problema del alzhéimer combatiendo los cúmulos de proteína beta-amiloide. Pero ¿y si el alzhéimer fuera, en realidad, un trastorno del sistema inmunitario dentro del cerebro?
À l'heure actuelle, les seuls médicaments approuvés pour la maladie d'Alzheimer se contentent de soulager certains symptômes - partiellement et temporairement - mais n'arrêtent pas la progression de la maladie. Shutterstock

Pourquoi n’avons‑nous pas de traitements contre la maladie d’Alzheimer ?

Connue officiellement depuis 115 ans, il n'y a toujours pas de traitement contre l'Alzheimer. Le cerveau humain est extrêmement complexe, et la maladie d'Alzheimer est sa maladie la plus complexe.
Currently, the only approved drugs for Alzheimer’s merely alleviate some of the symptoms — partially and temporarily — but do not stop the disease from progressing. (Shutterstock)

Why don’t we have a cure for Alzheimer’s disease?

It was first officially described 115 years ago, but we still do not have a cure for Alzheimer’s disease. The human brain is extremely complex, and Alzheimer’s is its most complex disease.
More than half of patients with dementia also suffer from depression. If the depression remains untreated, the associated memory and cognitive problems worsen. Conversely, a significant history of depression seems to be a risk factor for dementia. (Pixabay)

Depression and dementia in the age of COVID‑19: Two sides, one coin

Dementia and depression are two diagnoses that rob older adults of health and happiness. Despite their obvious differences, it is becoming ever more apparent that the two conditions are connected.
Dementia patients are often the perpetrators and often the victims of abuse. Research also shows that a medical history of head injury can more than double the risk of developing Alzheimer’s disease in some populations, even after many years. (Shutterstock)

Dementia’s hidden darkness: Violence and domestic abuse

From aggressive patients with Alzheimer’s to frustrated caregivers, dementia is increasingly entwined with violence in private homes and residential facilities.

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