Chloe James

Experience

• 2022–present
  Professor of Microbiology, University of Salford
• 2017–2022
  Senior Lecturer in Medical Microbiology, University of Salford
• 2012–2017
  Lecturer in Medical Microbiology, University of Salford
• 2009–2012
  Postdoctoral Researcher, University of Liverpool
• 2006–2008
  Postdoctoral Researcher - Marie Curie Funded, Universite Aix-Marseille
• 2003–2006
  Postdoctoral Researcher - NIH Funded, University of Florida

Education

• 2003 
  The University of Liverpool, PhD Microbiology
• 1998 
  The University of Edinburgh, BSc. hons Medical Microbiology

Publications

• 2026
  Exploring Phages Through Play: Creative 3D models for Science Engagement, Access Microbiology https://doi.org/10.1099/acmi.0.001158.v1
• 2024
  Antimicrobials: An update on new strategies to diversify treatment for bacterial infections, Advances in Microbial Physiology https://doi.org/10.1016/bs.ampbs.2023.12.002
• 2024
  Understanding the Impact of Temperate Bacteriophages on Their Lysogens Through Transcriptomics, J. Vis. Exp. doi:10.3791/64945
• 2021
  Comparative analysis of gene prediction tools for viral genome annotation , Biorxiv https://doi.org/10.1101/2021.12.11.472104
• 2021
  Antibiotic resistance profiles and population structure of disease-associated Staphylococcus aureus infecting patients in Fort Portal Regional Referral Hospital, Western Uganda, Microbiology https://doi.org/10.1099/mic.0.001000
• 2018
  Ram locus is a key regulator to trigger multidrug resistance in Enterobacter aerogenes, Journal of Medical Microbiology doi: 10.1099/jmm.0.000667
• 2017
  C. jejuni transcriptome changes during loss of culturability in water, PLoSOne doi: 10.1371/journal.pone.0188936
• 2017
  Evolutionary diversification of P. aeruginosa in an artificial sputum model, BMC Microbiology DOI:10.1186/s12866-016-0916-z
• 2017
  Fifty important research questions in microbial ecology, FEMS Microbiol Ecol https://doi.org/10.1093/femsec/fix044
• 2016
  The role of temperate bacteriophages in bacterial infection, FEMS Microbiology Letters doi10.1093/femsle/fnw015
• 2016
  Temperate phages enhance pathogen fitness in chronic lung infection, ISME J https://doi.org/10.1038/ismej.2016.51
• 2016
  Temperate phages both mediate and drive adaptive evolution in pathogen biofilms, PNAS https://doi.org/10.1073/pnas.1520056113
• 2015
  Lytic activity by temperate phages of Pseudomonas aeruginosa in long-term cystic fibrosis chronic lung infections, The ISME Journal. doi: 10.1038/ismej.2014.223
• 2015
  Polylysogeny magnifies competitiveness of a bacterial pathogen in vivo, Evolutionary Applications DOI: 10.1111/eva.12243
• 2014
  Recent Advances in Studies of Polymicrobial Interactions in Oral Biofilms, Curr Oral Health Rep https://doi.org/10.1007/s40496-013-0006-3
• 2014
  Role of environmental survival in transmission of Campylobacter jejuni, FEMS Microbiol. Letts. https://doi.org/10.1111/1574-6968.12488
• 2012
  Use of artificial sputum medium to test antibiotic efficacy against Pseudomonas aeruginosa in conditions more relevant to the cystic fibrosis lung, JoVE DOI : 10.3791/3857-v
• 2012
  Novel therapeutic strategies to counter Pseudomonas aeruginosa infections, Expert Reviews of Anti Infective Therapy DOI: 10.1586/eri.11.168
• 2012
  Differential infection properties of three inducible prophages from an epidemic strain of Pseudomonas aeruginosa , BMC Microbiology https://doi.org/10.1186/1471-2180-12-216
• 2011
  The effect of antibiotic treatment on bacteriophage production by a cystic fibrosis epidemic strain of Pseudomonas aeruginosa, AAC https://doi.org/10.1128/aac.01257-10
• 2010
  HIV protease inhibitors are substrates for OATP1A2, OATP1B1 and OATP1B3 and lopinavir plasma concentrations are influenced by SLCO1B1 polymorphisms, Pharmacogenetics and Genomics doi: 10.1097/FPC.0b013e328335b02d
• 2009
  How B-Lactam Antibiotics Enter Bacteria: A Dialogue with the Porins, PLoS One https://doi.org/10.1371/journal.pone.0005453
• 2008
  Membrane permeability and regulation of drug "influx and efflux" in enterobacterial pathogens, Curr Drug Targets https://doi.org/10.2174/138945008785747824
• 2008
  The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria, Nat Rev Microbiol. https://doi.org/10.1038/nrmicro1994
• 2007
  An Early Response to Environmental Stress Involves Regulation of OmpX and OmpF, Two Enterobacterial Outer Membrane Pore Forming Proteins, AAC. DOI:10.1128/AAC.01481-06
• 2007
  Intrinsic Apoptotic Pathways of Gingival Epithelial Cells Modulated by Porphyromonas gingivalis, Cell Microbiol. https://doi.org/10.1111/j.1462-5822.2007.00931.x
• 2007
  Short-tailed Stx Phages Exploit the Conserved YaeT Protein to Disseminate Shiga Toxin Genes Amongst Enterobacteria, J Bacteriol. https://doi.org/10.1128/JB.00824-07
• 2006
  A P. gingivalis Haloacid Dehalogenase Family Phosphatase Interacts with Human Phosphoproteins and is Important for Invasion, PNAS https://doi.org/10.1073/pnas.0509813103
• 2006
  S. gordonii utilizes several distinct gene functions to recruit P. gingivalis into a mixed community, Mol. Microbiol. doi:10.1111/j.1365-2958.2006.05099.x
• 2006
  Expression of the Short Fimbriae of Porphyromonas gingivalis is Regulated in Oral Bacterial Consortia , FEMS Microbiol. Lett. https://doi.org/10.1111/j.1574-6968.2006.00357.x
• 2006
  LuxS Involvement in the Regulation of Genes Coding for Hemin and Iron Acquisition Systems in Porphyromonas gingivalis , Infect. Immun. doi: 10.1128/IAI.01768-05
• 2005
  Survival of shiga toxin-encoding bacteriophage in a compost model, FEMS Microbiol Letts. DOI:10.1016/j.femsle.2005.03.031
• 2003
  Immunity profiles of wild-type and recombinant verotoxin-encoding bacteriophages and characterization of novel double lysogens, Infect Immun. doi: 10.1128/IAI.71.6.3409-3418.2003
• 2001
  Lytic and lysogenic infection of diverse Escherichia coli and Shigella strains by verotoxigenic bacteriophages, Appl Environ Microbiol. doi: 10.1128/AEM.67.9.4335-4337.2001
• 2001
  Phage mediated transfer of virulence genes, J Chem Tech Biotech. https://doi.org/10.1002/jctb.437

Grants and Contracts

• 2025
  Relationship Building - Bridging the gap between basic laboratory studies and clinical trials in wound healing biotechnology

  Role:

  PI

  Funding Source:

  IBIC

• 2024
  Immersive tools for active and creative engagement in STEM subjects

  Role:

  PI

  Funding Source:

  HEIF

• 2021
  Antimicrobial Surface Coatings for Controlling Infection Transmission

  Role:

  Co-I

  Funding Source:

  HEIF

• 2020
  Prophage host interactions: pulling back the curtains on Pseudomonas puppet masters

  Role:

  PI

  Funding Source:

  BBSRC BB/T016256/1

Professional Memberships

• The Microbiology Society
• Applied Microbiology International