Keira Bell, one of the claimants in the High Court case, was prescribed puberty blockers at 16. EPA-EFE/ FACUNDO ARRIZABALAGA December 10, 2020 What are puberty blockers, and how do they work? Faisal Ahmed, University of Glasgow and Angela Lucas-Herald, University of Glasgow So-called “puberty blockers” work by temporarily suppressing the action of a specific hormone in the body.